PRP Therapy: The Next Level of Rejuvenative Skin, Hair & Regenerative Care
By Andrea Del-Olmo, ND
Naturopathic Physician & Co-Owner,
Venya Medical Spa
At Venya Medical Spa in Portland, Oregon, we specialize in integrative skin care and regenerative therapies, including Platelet-Rich Plasma (PRP). PRP is one of the most exciting advances in modern aesthetic and regenerative medicine because it uses your body’s own biology to stimulate healing, rejuvenation, and renewal.
Clinically, we use PRP primarily for skin rejuvenation and hair restoration, and we are now proud to offer Cellenis® Derma PRP™, an innovative autologous skin volumizer that allows us to address volume loss and skin quality—often reducing the need for traditional dermal fillers.
What Is PRP Therapy and How Does It Work?
Platelet-Rich Plasma (PRP) is derived from a patient’s own blood and processed to concentrate platelets and plasma rich in growth factors, cytokines, and bioactive proteins. These signaling molecules play an essential role in:
- Collagen and elastin synthesis
- Cellular proliferation and tissue repair
- Angiogenesis (new blood vessel formation)
- Modulation of inflammation and wound healing
The biological mechanisms behind PRP are well described in dermatologic and regenerative medicine literature, including its effects on fibroblast activation and extracellular matrix remodeling
(Alves & Grimalt, 2018;
Everts et al., 2020).
Medical & Aesthetic Uses of PRP
PRP for Skin Rejuvenation
PRP has been extensively studied for facial rejuvenation, with research demonstrating improvements in:
- Skin texture and tone
- Fine lines and wrinkles
- Elasticity and dermal thickness
- Acne scarring and overall skin quality
Histologic studies show increased fibroblast proliferation and collagen deposition after PRP treatment
(Singh et al., 2020).
A
2025 meta-analysis of randomized controlled trials found that PRP significantly improved facial skin quality and patient satisfaction compared with controls
(Lv et al., 2025).
PRP is often used:
- As intradermal injections
- In combination with
microneedling, which further enhances collagen induction and growth-factor signaling
(Asubiaro et al., 2024).
Cellenis®™ Derma PRP™: Autologous Skin Volumization
Cellenis®™ Derma PRP™ represents a newer application of PRP technology, using a proprietary process to create a biologic, autologous volumizing matrix.
Unlike hyaluronic acid fillers, this approach:
- Uses 100% autologous plasma and platelets
- Supports tissue regeneration and collagen formation
- Provides subtle, natural-appearing volume
While large-scale randomized trials specific to PRP-based volumizers are still emerging, the regenerative mechanisms underlying PRP’s volumizing and dermal-thickening effects are well supported in the literature
(Everts et al., 2020;
Singh et al., 2020).
PRP for Hair Restoration
PRP is one of the most researched regenerative therapies for androgenetic alopecia and non-scarring hair loss.
Growth factors in PRP stimulate dermal papilla cells, prolong the anagen (growth) phase, and improve follicular vascularization(Gupta et al., 2019).
A
systematic review and meta-analysis demonstrated significant improvements in hair density and hair count in patients receiving PRP compared with placebo or baseline
(Gupta et al., 2019).
Best outcomes are consistently associated with a series of treatments, rather than a single session.
PRP for Joints & Musculoskeletal Health
PRP has a strong evidence base in orthopedic and sports medicine, particularly for osteoarthritis and chronic tendinopathies.
Systematic reviews indicate PRP may:
- Reduce pain
- Improve joint function
- Modulate inflammatory signaling
Outcomes depend on platelet concentration, preparation technique, and injection accuracy
(Johns Hopkins Medicine).
Intrauterine PRP (Emerging Use)
PRP has been explored in reproductive medicine for thin endometrium and recurrent implantation failure.
A
systematic review and meta-analysis found PRP may improve endometrial thickness and pregnancy outcomes, though authors emphasize the need for further randomized trials
(Molina et al., 2023).
Why Provider Expertise Matters
Clinical outcomes with PRP depend heavily on:
- Strict sterile technique
- Optimized platelet concentration
- Appropriate centrifugation and handling
- Clinician training and anatomical expertise
Variability in PRP preparation is a major reason outcomes differ across studies and practices
(Alves & Grimalt, 2018).
PRP Works Best as a Series
PRP is a biologic, regenerative therapy, and its effects are cumulative:
- Skin rejuvenation: 2–3 treatments, 4–6 weeks apart
- Hair restoration: 3–4 treatments initially
- Maintenance: Often yearly or bi-yearly
At Venya Medical Spa, we tailor treatment plans to your goals, biology, and long-term rejuvenation strategy.
Frequently Asked Questions About PRP
Is PRP safe?
Yes. PRP is autologous, meaning it comes from your own blood, and has an excellent safety profile when performed using sterile technique
(Singh et al., 2020).
When will I see results?
Skin results often appear within 4–8 weeks; hair restoration typically takes 3–6 months due to hair growth cycles.
Can PRP replace fillers?
For select patients,
Cellenis® Derma PRP™ can provide volume and improved skin quality, reducing reliance on synthetic fillers.
Book a PRP Consultation at Venya Medical Spa
If you’re interested in PRP for skin rejuvenation, hair restoration, or natural facial volumization, we invite you to schedule a personalized consultation at Venya Medical Spa in Portland, Oregon.
Your body already knows how to heal — PRP helps activate that potential.
References (Linked)
- Alves R, Grimalt R.
A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification.
Skin Appendage Disord. 2018.
https://pubmed.ncbi.nlm.nih.gov/29484006/ - Everts PAM et al.
Platelet-Rich Plasma and Platelet Gel: A Review.
J Extracell Vesicles. 2020.
https://pubmed.ncbi.nlm.nih.gov/33118132/ - Singh S et al.
Platelet-Rich Plasma in Dermatology: A Review of Evidence.
J Cosmet Dermatol. 2020.
https://pubmed.ncbi.nlm.nih.gov/31904080/ - Lv X et al.
Efficacy of Platelet-Rich Plasma in Facial Rejuvenation: A Meta-Analysis.
Aesthetic Surgery Journal Open Forum. 2025.
https://academic.oup.com/asjopenforum/article/7/1/ojaf150/8322866 - Asubiaro T et al.
Platelet-Rich Plasma in Aesthetic Dermatology: Systematic Review.
Dermatologic Therapy. 2024.
https://pubmed.ncbi.nlm.nih.gov/39268288/ - Gupta AK et al.
PRP for Androgenetic Alopecia: Systematic Review and Meta-Analysis.
J Cutan Med Surg. 2019.
https://pubmed.ncbi.nlm.nih.gov/30606055/ - Johns Hopkins Medicine.
Platelet-Rich Plasma (PRP) Treatment Overview.
https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/platelet-rich-plasma-prp-treatment
Molina A et al.
Intrauterine PRP for Thin Endometrium: Systematic Review and Meta-Analysis.
Reproductive Biology and Endocrinology. 2023.
https://rbej.biomedcentral.com/articles/10.1186/s12958-023-01079-1